New research reveals that people who stop using blockbuster weight-loss injections like semaglutide or tirzepatide can put back on lost weight far faster than those who end traditional lifestyle regimens.
Published data in a major medical journal shows that while obese people can lose about a fifth of their body weight while on the medication, the mass is regained at an average rate of nearly a kilo each month upon discontinuation.
"People using these drugs should be cognizant of the risk of quick rebound weight gain when the medication ends," cautioned expert Dr. Susan Jebb.
Such speed of recovery means a reversion to starting weight within about 18 months.
Weighing Approaches
The analysis, which examined dozens of trials involving thousands of patients, contrasted the outcomes of the injectable medications with older methods.
Scientists point out that individuals who shed pounds through dieting generally experience a less rapid creep back—approximately 100 grams monthly—after stopping.
Understanding the Quick Regain
Experts propose the mechanism of the jabs accounts for the heightened regain.
The injections copy a natural hormone called GLP-1, which controls feelings of fullness.
"Long-term administration of the hormone levels far above than the body's typical production could lead to the system to produce less of its endogenous hormone, and may also diminish sensitivity to its actions," said Dr. Adam Collins, a nutrition specialist.
"Discontinuation of this GLP-1 'fix' means hunger is no longer kept in check, making excessive eating a significant risk."
A Lifelong Issue?
The NHS recommend the injections for people with obesity-related medical conditions, alongside prescribed diet and exercise modifications.
A number of clinicians argue that, considering the likelihood of weight regain, the therapy should be considered long-term.
This opinion is echoed by drug manufacturers, who say that the results "highlight the long-term character of excess weight," akin to managing conditions like diabetes.
Patient Accounts
People who have come off the jabs describe a intense return of hunger.
"It was like a switch activating and you're instantly starving," said one woman.
This challenge is exacerbated if individuals have not established permanent dietary or behavioural changes during treatment.
Widespread Adoption
Figures suggest that millions of adults in the UK have used weight-loss jabs in the past year, with demand continuing to grow.
- Adoption is greater among females compared to men.
- The middle-aged demographic shows the highest level of interest.
- Many access the medications through private healthcare rather than the NHS.
Finally, experts emphasize that while the jabs are potent agents for shedding pounds, they are not a standalone solution and long-term success likely depends on ongoing lifestyle support.
